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Premier Research has four clinical research centers in the United States devoted exclusively to analgesic studies. Each of the centers has multiple experienced investigators and a full-time Premier Research staff highly trained and experienced in pain measurement. Our sites offer state-of-the-art recruiting and research facilities plus the ability to handle the most scientifically demanding trials in important analgesic indications. Each Research Center is able to perform rapid, proof-of-concept, dose-ranging, single or multiple-dose studies, offers dormitory and extended stay capabilities, and can perform inpatient multiple- or single-day pharmacokinetic and pharmacodynamic studies.
Our site management expertise allows our sponsors’ studies to be up and running quickly, resulting in a multitude of significant benefits such as:
- Rapid Study Start-ups – With a centrally managed network employing consistent management practices, we can expedite the process of site selection, IRB interaction and approvals, regulatory documentation packages and budget/contract negotiation.
- Efficient Patient Recruitment and Scheduling – Our rapid telephone recruitment and screening system eliminates wasted time and effort and enhances enrollment of qualified patients. The location of our clinics in Austin, San Marcos and Salt Lake City, makes it well situated for efficient recruitment. Each location has a diverse large population that includes a pool of students at nearby colleges.
- More Accurate Data – Patient testing and evaluation are vitally important in drug trials, especially in areas such as analgesia, where data is mainly derived from subjective reports. At the Research Centers, our personnel are trained in consistent evaluation and assessment techniques – leading to cleaner, clearer and more accurate data.
The Analgesia Model Development Team at Premier Research is highly experienced in the development and validation of novel models for analgesic research. The purpose of the Analgesia Development Program is to meet the challenges of present day drug development by developing models with a high degree of scientific validity that are also able to address such practical considerations as rapid recruitment and reduction in the signal-to-noise ratio. For example, the post-operative bunionectomy model developed by the team has reduced patient recruitment times by 30-40% using a small number of sites while providing assay sensitivity equal to or better than existing post-operative surgical models.
Other methodologies developed or refined by the Premier Research team include:
- Third molar extraction (wisdom teeth)
- Orthopedic/Podiatric surgery (bunionectomy and hammertoe surgery, knee arthroscopy, ACL repair, knee/hip replacement)
- General/Gynecologic surgery (hernia repair, cholecystectomy, hysterectomy)
- Pioneered Sciatic Block anesthesia techniques for bunionectomy
- Multi-day/Multiple dose designs for acute pain
- Dysmenorrhea repeated dose model
- Pre-surgical anxiety model
- Postoperative nausea & vomiting model
- Two stopwatch method for onset measures
Services- Multi-day/Multi-dose Studies
- Phase 1b-4 Clinical Studies
- Specialty Phase 1 Healthy Volunteers Studies
- Proof-of-Concept Studies
- Dose-Ranging Studies
- PK and PD Studies
- In-patient and Out-patient Capabilities
- Novel Model Development
To volunteer for a clinical study at one of the Clinical Research Centers, please click here.
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